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Krüppel样因子(KLFs)家族属于真核生物中含锌指结构转录因子家族。该家族成员在多种细胞系中均有表达,主要参与细胞生长、增殖、分化及凋亡等多个生命活动的调控。Krüppel样因子4(KLF4)是KLF家族中研究较多的成员之一。随着对KLF4研究的不断深入,该蛋白的生物学功能以及与肿瘤、心血管疾病等老年人常患疾病的关系已经逐渐明确。由于KLF4蛋
The Krüppel-like factor (KLFs) family belongs to the family of zinc finger-based transcription factors in eukaryotes. The members of the family are expressed in many cell lines and are mainly involved in the regulation of multiple life activities such as cell growth, proliferation, differentiation and apoptosis. Krüppel-like factor 4 (KLF4) is one of the more studied members of the KLF family. With the deepening of the research on KLF4, the biological function of this protein has gradually been clarified as well as the relationship with the diseases often associated with the elderly such as cancer and cardiovascular diseases. Due to KLF4 egg