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目的 :研究在双特异性抗体的介导下CD3AK细胞 (CD3单克隆性激活的杀伤细胞 )对人小细胞肺癌细胞株LTEP sm1的细胞毒作用。方法 :用51Cr Na2 CrO4 释放试验检测单抗 (2D6、UCHT1)和双特异性抗体 (WST H7)与CD3AK共同对人小细胞肺癌细胞株的杀伤活性。结果 :双特异性抗体体外能明显增强CD3AK细胞对人小细胞肺细胞株LTEP sm1的杀伤活性。结论 :与单纯CD3AK相比 ,加入双特异性抗体后的CD3AK细胞的细胞毒活性显著增强
AIM: To investigate the cytotoxic effect of CD3AK cells (CD3 monoclonal activated killer cells) on human small cell lung cancer cell line LTEP sm1 mediated by bispecific antibodies. Methods: The cytotoxic activity of monoclonal antibody (2D6, UCHT1) and bispecific antibody (WST H7) combined with CD3AK on human small cell lung cancer cell line was detected by 51Cr Na2 CrO4 release assay. Results: Bispecific antibody could significantly enhance the killing activity of CD3AK cells against LTEP sm1 in vitro. CONCLUSION: Compared with CD3AK alone, the cytotoxic activity of CD3AK cells after addition of bispecific antibody was significantly increased