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联合使用β阻滞剂心得安和钙拮抗剂硝吡胺甲酯(Nicardipine)可帮助减少或消除“无症状性缺血”,因此减少了慢性稳定型心绞痛病人的发病率 加利福尼亚大学的Raman Singh医师对31名患有慢性稳定型心绞痛的病人进行了研究,与安慰剂相比,mg心得安(每日3次)和30mg硝吡按甲酯(每日3次)联合用药,可减少24小时内90％以上病人的无症状缺血发作和缺血时间。 他说,单独给予病人硝吡胺甲酯或心得安时,对无症状缺血发作的次数和持续时间均无明显作用。 单独使用心得安可使心绞痛发作减少45％,联合用药减少43％,但硝吡胺甲酯本身对心绞痛病人几乎无效。心得安可使静止和最大运动心率减少％,联合药物减少26％,而硝吡胺甲酯使心率仅减少9％。
The combination of beta blocker propranolol and nicardipine, a calcium antagonist, helps reduce or eliminate “asymptomatic ischemia,” thus reducing the incidence of patients with chronic stable angina. Dr. Raman Singh, MD, of University of California, A study of 31 patients with chronic stable angina pectoris, medroxyprogesterone acetate (3 times daily) and 30 mg nitroprusside (3 times daily), reduced 24 hours compared with placebo Asymptomatic ischemic attack and ischemic time in more than 90% of patients. He said that patients given nitrendipamide or propranolol alone had no significant effect on the number and duration of asymptomatic ischemic attacks. Amphenol alone reduces the incidence of angina attacks by 45% and the combination regimen by 43%, but nicardipine itself is almost ineffective in patients with angina. Enzianne allowed a reduction of% in resting and maximal exercise heart rate, a 26% decrease in combination medication, and nicardipine reduced heart rate by only 9%.