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目的了解该院耐甲氧西林金黄色葡萄球菌(MRSA)的临床分布、易感因素和耐药情况。方法回顾性分析2015年MRSA感染患者42例的临床病历资料,调查患者的临床状况,分析抗菌药物的应用情况,记录MRSA药物敏感试验结果,分析MRSA感染分布特征。结果 MRSA分离标本以血液和痰液较多,长期住院、基础疾病多、免疫力低下、入住重症监护病房(ICU)、接受机械通气、使用多种抗菌药物是引起MRSA感染的主要危险因素。结论MRSA是引起医院感染的重要病原菌之一,对许多抗菌药物耐药严重,应根据药敏结果合理使用,加强病区的消毒隔离和医务人员无菌操作,以降低其发病率。
Objective To investigate the clinical distribution, susceptibility factors and drug resistance of methicillin-resistant Staphylococcus aureus (MRSA) in this hospital. Methods Clinical data of 42 patients with MRSA infection in 2015 were analyzed retrospectively. The clinical condition of the patients was analyzed. The application of antimicrobial agents was analyzed. The MRSA drug susceptibility test results were recorded and the distribution of MRSA infection was analyzed. Results The majority of MRSA isolates were blood and sputum, long-term hospitalization, multiple underlying diseases, low immunity, intensive care unit (ICU) admission, mechanical ventilation, and multiple antimicrobial agents were the main risk factors for MRSA infection. Conclusions MRSA is one of the most important pathogenic bacteria causing nosocomial infection. It is resistant to many antimicrobial agents. It should be used reasonably based on the results of drug susceptibility test. It should be used to reduce the incidence of MRSA.