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氢氧化铝是研究治疗胃、十二指肠溃疡(GU、DU)的恰当抗酸药,很多制剂都含镁盐以减轻氢氧化铝所致便秘的副作用,称铝镁抗酸剂.近几年来,不少报告显示抗酸剂有促进DU愈合的效果,而对GU的疗效尚无仔细的研究,但晚近报告疗效显著。并发现所需的量比以往要少得多,从而增加了与其他抗溃疡药的竞争力。抗酸剂治疗DU的疗效 本世纪内,抗酸剂曾用于治疗消化不良。1677年Petersbn等首次报告抗酸药对DU的愈合有效,在研究中分别于餐后1、3小时和睡前各给药一次,每日七次,每次30ml。这样多次大量给药可使胃内pH保持在高值状态。治
Aluminum hydroxide is an appropriate antacid for studying the treatment of gastric and duodenal ulcer (GU, DU). Many preparations contain magnesium salt to reduce the side effects caused by aluminum hydroxide-induced constipation. In recent years, many reports show that antacids have the effect of promoting DU healing. However, the curative effect of GU has not been studied carefully, but recent reports have shown significant effects. And found that the amount needed was much less than before, increasing the competitiveness with other anti-ulcer agents. Antacid therapy for DU This century, antacids have been used to treat indigestion. In 1677, Petersbn et al reported for the first time that antacids were effective in DU healing. In the study, they were administered once or three times a day at bedtime, 1h, 3h and before going to bed respectively, 30ml each time. Such multiple administrations can keep the gastric pH at a high value. rule