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2型糖尿病患者220例,依据年龄分A组:年龄≧60岁,140例;B组:年龄≦40岁8,0例。同期健康体检者为C组,年龄≧60岁,120例。检测他们的血脂、空腹血糖、糖化血红蛋白(HbA1c)和踝臂指数(ABI),组间数据进行t检验,并将血脂、HbA1c与ABI进行相关性分析。结果A组与B组相比,两组的血脂、血糖无统计学差异(P>0.05),A组ABI水平明显降低(P<0.05)。与C组相比,A组的HDL明显降低(P<0.05),其它血脂水平明显升高(P<0.05),ABI水平明显降低(P<0.05)。A组各种血脂的均值都在正常人参考值范围内,但是TC(应<4.5 mmol/L-1)和TG(应<1.5 mmol/L-1)未达到糖尿病患者的血脂治疗指标。TC、TG、LDL-C和Lp(a)与HbA1c均呈正相关,与ABI均呈负相关(P<0.05);HDL-C与HbA1c呈负相关,与ABI呈正相关(P<0.05)。HbA1c与ABI呈负相关。结论老年T2DM患者血脂与年轻患者相同,但比同龄正常人严重,并与下肢外周血管的功能下降相关。患者在控制血糖的同时,还应调节血脂才能更好地防治外周血管病变。
220 cases of type 2 diabetes, according to age group A: age 60 years old, 140 cases; group B: age 40 years old 8,0 cases. Health examination over the same period for the C group, age ≧ 60 years old, 120 cases. Their blood lipids, fasting blood glucose, glycosylated hemoglobin (HbA1c) and ankle-brachial index (ABI) were measured. T-test was used to compare the data of blood lipid, HbA1c and ABI. Results Compared with group B, there was no significant difference in blood lipid and blood glucose between group A and group B (P> 0.05). The ABI level of group A was significantly lower than that of group B (P <0.05). Compared with group C, HDL in group A was significantly decreased (P <0.05), other lipid levels were significantly increased (P <0.05), ABI levels were significantly decreased (P <0.05). A group of various blood lipid mean values in the normal reference range, but TC (should be <4.5 mmol / L-1) and TG (should <1.5 mmol / L-1) did not meet the lipid-lowering treatment of diabetic patients. The levels of TC, TG, LDL-C and Lp (a) were positively correlated with HbA1c and negatively correlated with ABI (P <0.05). HDL-C was negatively correlated with HbA1c and positively correlated with ABI (P <0.05). HbA1c was negatively correlated with ABI. Conclusion The elderly patients with T2DM have the same level of serum lipids as younger patients, but are more severe than their normal peers and associated with decreased peripheral vascular function. Patients in the control of blood sugar at the same time, it should regulate blood lipids in order to better prevent peripheral vascular disease.