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目的:探讨影响儿童急性淋巴细胞白血病(ALL)首次化疗结果的因素分析为临床治疗提供依据。方法:对华中科技大学同济医学院附属同济医院儿科139例ALL患儿首次化疗的有关指标与化疗效果(完全缓解或非完全缓解)的关系进行单因素和Logistic多因素分析。结果:单因素结果提示除年龄及外周血白细胞计数与首次化疗CR有关,其余各项变量均与首次化疗CR无关。Logistic多因素分析显示,外周血白细胞计数(OR=-0.636,95%CI为0.30～0.95,P=0.003)是导致儿童ALL首次化疗非完全缓解的主要危险因素。结论:对于伴外周血高白细胞的儿童ALL,其首次化疗完全缓解率较低,应引起医师的高度重视。
Objective: To investigate the factors influencing the outcome of the first chemotherapy in children with acute lymphoblastic leukemia (ALL) to provide the basis for clinical treatment. Methods: One-factor and logistic multivariate analysis was performed on the relationship between the index of chemotherapy and the effect of chemotherapy (complete or partial response) in 139 pediatric patients with ALL with the Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology. Results: The univariate results suggested that except for age and peripheral blood leukocyte count were related to the first chemotherapy CR. The remaining variables were not related to the first chemotherapy CR. Logistic multivariate analysis showed that peripheral white blood cell count (OR = -0.636, 95% CI 0.30-0.95, P = 0.003) was the major risk factor for incomplete response to initial chemotherapy in children with ALL. Conclusions: For ALL children with peripheral blood leukocytes, the first complete response rate of chemotherapy is low, which should be paid great attention to by physicians.