血管活性因子在维持正常血压以及在高血压发病中的作用,已越来越受到广泛重视。大量研究提示,血管活性因子除对血管平滑肌有收缩舒张作用外,还具有很多其它生物功能,对细胞增殖、增长的影响;对神经系统的影响;对水电解质平衡的影响等。而血管活性因子对血压的影响,则是它们多种功能的总和。本文将对近年该方面的研究进展进行综述,主要就肾素-血管紧张素系统(RAS)、内皮素(ET)、心钠素(ANP)、内皮细胞由来性舒张因子(EDRF)等的作用进行讨论。 Vasoactive factors in maintaining normal blood pressure and the role in the pathogenesis of hypertension has been more and more widespread attention. Numerous studies suggest that, in addition to vascular smooth muscle contraction and relaxation of vasodilators, but also has many other biological functions, the impact on cell proliferation and growth; the impact on the nervous system; the impact on water and electrolyte balance. The effect of vasoactive factors on blood pressure is the sum of their multiple functions. This article reviews the research progress in this area in recent years, mainly on the effects of renin-angiotensin system (RAS), endothelin (ET), atrial natriuretic peptide (ANP), endothelial relaxing factor (EDRF) have a discussion.