发表在《Diabetologia》杂志上的一项基于人群的观察性研究结果显示,绝经后乳腺癌幸存者糖尿病的患病率有一个小幅但有意义的增加,而且乳腺癌幸存者糖尿病发病率随时间变化。癌症和糖尿病之间的潜在关系越来越被人们所认可。例如,糖尿病妇女绝经后患乳腺癌风险比非糖尿病人群高出约20%,并且在乳腺癌诊断后死亡率增加了50%。这之间的关系可能与胰岛素抵抗和高胰岛素血症的作用有关,因为这两者都是已知的2型糖尿病和癌症的共同危险因素。在我们的研究中,比较了24,976名新诊断的乳腺癌妇女和124,880名年龄匹配但没有患乳腺癌的妇女的糖尿病发病率。病例组和对照组患者均来自安大略省的以人群为基础的数据库。在随访期间,乳腺癌妇女 A population-based observational study published in the journal Diabetologia shows a small but significant increase in the prevalence of diabetes in postmenopausal breast cancer survivors, and the incidence of diabetes in breast cancer survivors varies over time . The potential relationship between cancer and diabetes is increasingly recognized. For example, women with diabetes have a 20% higher risk of developing breast cancer after menopause than non-diabetic individuals and a 50% increase in mortality after breast cancer diagnosis. The relationship between this may be related to the role of insulin resistance and hyperinsulinemia, both of which are known to be common risk factors for type 2 diabetes and cancer. In our study, the prevalence of diabetes in 24,976 newly diagnosed breast cancer women and 124,880 age-matched but non-breast cancer women was compared. Patients in the case and control groups were all from Ontario based population-based databases. During follow-up, breast cancer women