在急性失代偿心力衰竭治疗过程中发生的肾功能恶化往往使心力衰竭的治疗更加艰难和复杂化。其机制可能与动脉充盈、肾脏灌注、静脉淤血和腹内压升高有关。传统上,肾功能损伤的诊断通常是通过测定血清肌酐。一些较新的生物学标志物被认为可能对早期诊断急性肾损伤有帮助,其中包括中性粒细胞明胶酶相关脂质运载蛋白、半胱氨酸蛋白酶抑制剂C等,其指标的升高均早于血清肌酐的升高,并且有望在不久的将来应用于临床实践中。 Deterioration of renal function during treatment of acute decompensated heart failure often renders the treatment of heart failure more difficult and complicated. The mechanism may be related to arterial filling, renal perfusion, venous congestion and increased intra-abdominal pressure. Traditionally, the diagnosis of renal impairment is usually by measuring serum creatinine. Some of the newer biomarkers are considered to be potentially useful in the early diagnosis of acute kidney injury, including neutrophil gelatinase-associated lipocalin, cystatin C and the like, both of which are elevated Before the rise of serum creatinine, and is expected to be used in clinical practice in the near future.