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白血病细胞是否能在一定条件下继续向成熟方向分化,是近20年来肿瘤细胞生物学研究的重要课题。自1971年Friend等人首先报道二甲基亚砜(DMSO)可诱导小鼠红白血病细胞系中大多数细胞向成熟红系分化以来,白血病细胞特别是人白血病细胞体外诱导分化的工作引起越来越多人的兴趣,成为目前白血病研究较活跃的一个领域。现就这方面的一些工作简要介绍如下。一、白血病细胞具有一定自发分化能力白血病细胞并未完全丧失成熟分化能力。体外培养及体内均
Leukemia cells under certain conditions continue to mature direction of differentiation, tumor cell biology nearly 20 years of research an important issue. Since Friend et al. First reported in 1971 that dimethyl sulfoxide (DMSO) induced the differentiation of most of the erythroleukemia cell lines in mice to mature erythroid cells, the leukemic cells, especially human leukemia cells, induced differentiation in vitro The more people’s interest has become an active area of leukemia research. Now some of the work in this area are briefly described below. First, leukemia cells have a certain degree of spontaneous differentiation Leukemia cells have not completely lost the ability of mature differentiation. In vitro culture and in vivo