【摘 要】
：
以二棕榈酰卵磷脂(DPPC)、磷脂酰甘油(PG)、脱脂高密度脂蛋白(AP-HDL)配制成人工表面活性物质,以其在体外的表面活性及对离体鼠肺压力-容量曲线的影响,与猪的天然PS作比较。
【机 构】
：
上海医科大学儿科医院,上海医科大学儿科医院,上海医科大学药学院生化教研室,上海医科大学药学院生化教研室,上海医科大学药学院生化教研室
论文部分内容阅读
以二棕榈酰卵磷脂(DPPC)、磷脂酰甘油(PG)、脱脂高密度脂蛋白(AP-HDL)配制成人工表面活性物质,以其在体外的表面活性及对离体鼠肺压力-容量曲线的影响,与猪的天然PS作比较。结果显示,二者在体外均能降低表面张力,提高离体鼠肺的顺应性,在统计学上两者无显著性差异。因此,这种人工表面活性物质有可能成为肺表面活性物质替代治疗的一种制剂。
The artificial surfactant was formulated with dipalmitoyl phosphatidylcholine (DPPC), phosphatidylglycerol (PG) and defatted high density lipoprotein (AP-HDL), and its surface activity in vitro and its effect on the pressure- The effect of the curve is compared with the pig’s native PS. The results showed that both in vitro can reduce the surface tension and improve the compliance of isolated rat lung, statistically no significant difference between the two. Therefore, this artificial surfactant may become an alternative to the treatment of pulmonary surfactant.
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