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目的:探讨补体因子H(n CFH)基因单核苷酸多态性(SNPs)与糖尿病人群无法解释的轻度视力损伤(UMVL)的相关性。n 方法:采用病例对照研究方法，2016年4—7月在上海市新泾社区进行2型糖尿病患者流行病学调查，收集受检者的基本信息、眼科检查和血生物化学检验结果，采集每例患者的清晨空腹外周血2 ml用于提取DNA。采用Fluidigm法对n CFH基因上的5个SNPs rs800292、rs1061170、rs529825、rs1410996和rs203674进行基因型检测，采用SPSS 13.0统计学软件和Haploview 4.0软件计算Hardy-Weinberg平衡、碱基型和基因型频率，进行关联分析和单倍体分型并评估各SNPs与UMVL之间的关系。n 结果:共纳入135例无法解释的视力轻度损伤的糖尿病患者作为试验组，133例视力正常的糖尿病患者作为对照。rs2003674位点不符合Hardy-Weinberg平衡，未纳入分析。在纳入分析的n CFH基因的其他4个位点rs529825、rs800292、rs1410996、rs1061170中，2组之间SNPs及基因型均无明显差异，其等位基因频率n P值分别为0.79、0.25、0.69和0.77；其基因型频率n P值分别为0.61、0.69、0.87和0.43。n 结论:CFH基因多态性导致的个体补体系统差异与糖尿病患者UMVL无相关性。n “,”Objective:To investigate whether the presence of complement factor H(n CFH) gene polymorphisms is associated with unexplained mild visual loss (UMVL) in type 2 diabetes mellitus patients.n Methods:A case control study was adopted.The participants included two groups from a previous population-based epidemiology study on type 2 diabetes mellitus patients in the Beixinjing community, Shanghai: UMVL was defined by a best corrected visual acuity(BCVA)0.05). The four SNPs(rs800292, rs1061170, rs529825, rs1410996) except rs203674 tested in the UMVL and control groups were qualified by the Hardy-Weinberg equilibrium (n P>0.05). There were no differences in SNPs and genotypes between the two groups in the four loci of then CFH gene.The n P value of allele frequencies of rs529825, rs800292, rs1410996 and rs1061170 were 0.79, 0.25, 0.69 and 0.77, respectively, and the n P value of genotype frequencies were 0.61, 0.69, 0.87 and 0.43, respectively.n Conclusions:There is no correlation between n CFH gene polymorphism and UMVL in type 2 diabetic patients.n