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目的 探讨双相障碍混合状态与双相障碍抑郁发作临床特征的差异性,为临床诊治提供依据.方法 对62例双相障碍混合状态患者(双相混合组)和44例双相障碍抑郁发作患者(双相抑郁组)的性格特征、精神症状、躯体症状等临床特征进行回顾性分析.结果 双相混合组性格特征的急躁、固执、易怒、冲动阳性率显著高于双相抑郁组(P<0.05或0.01);精神症状的心境不稳定发作、睡前浮想联翩、烦躁、愤怒、思维加速、强迫阳性率显著高于双相抑郁组(P<0.05或0.01),自责、自卑、低落、忧愁阳性率显著低于双相抑郁组(P<0.05或0.01);躯体症状的头痛、睡眠需要减少、心慌阳性率显著高于双相抑郁组(P<0.05或0.01),多梦、睡眠过多阳性率显著低于双相抑郁组(P<0.05).结论 双相障碍混合状态患者急躁、固执、易怒、冲动的性格特征较双相障碍抑郁发作患者更突出,二者精神症状、躯体症状具有差异性,可作为特征性筛查的观察指标.“,”Objective To explore the differences of clinical features of mixed state and depressive phase of bipolar disorder. Methods Clinical features of 62 patients with mixed state of bipolar disorder (mixed group) and 44 ones with depressive phase (depression group) retrospectively analyzed. Results Positive rates of character traits such as impatience,adherence,irritability and impulsion were significantly higher in mixed than depression group (P<0.05 or 0.01). Positive rates of mental symptoms such as unstable mood,pre-sleep indulging in free association,fretfulness,flight of thought and obsession were significantly higher (P<0.05 or 0.01) and those of self-accusation,self-abasement,lowness and sadness lower (P<0.05 or 0.01) in mixed than depression group;positive rates of physical symptoms such as headache,sleep need decrease and palpitation were significantly higher (P<0.05 or 0.01) and those of dreaminess and drowsiness lower (P<0.05) in mixed than depression group. Conclusion Character traits of impatience,adherence,irritability and impulsion are more outstanding in patients with mixed state of bipolar disorder than in ones with depressive phase,their mental and physical symptoms have differences and can be used as observation indexes for characteristic screening.