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目的对慢性乙肝病毒携带者的肝组织病理结果进行分析与研究。方法将2015年2月-2017年2月到医院接受治疗的慢性乙肝病毒携带患者108例选取为研究对象,对患者采取肝功能、血常规及凝血酶原时间检测,并对患者的肝组织病理结果进行分析。结果 108例患者中存在不同程度病理学变化有105例,占97.22%,其中48例为G_1S_0或G_0S_1,占44.44%;3例为G_1S_0,占2.78%;57例为S_2或G_2以上,占52.78%。血清HBV-DNA<105copies/ml患者与血清HBV-DNA>105copies/ml患者的纤维化分期与肝组织炎症分级等均差异无统计学意义(P>0.05)。随着年龄的不断增加,患者的纤维化程度和肝组织炎症程度会越来越严重,>40岁的患者的纤维化程度和肝组织炎症程度明显高于<40岁的患者,>40岁的患者的S2-4和G2-4的占比均明显高于<40岁的患者,差异均有统计学意义(P<0.05)。结论慢性乙肝病毒携带患者均会伴有不同程度的肝组织病理学改变,而且年龄越大,其纤维化程度和肝组织炎症程度越严重,但纤维化程度和肝组织炎症程度与血清HBV-DNA水平无太大关联。
Objective To analyze and study the histopathological results of liver in chronic hepatitis B virus carriers. Methods A total of 108 patients with chronic hepatitis B virus who were admitted to the hospital from February 2015 to February 2017 were enrolled in the study. Liver function, blood routine and prothrombin time were detected in patients. Liver pathology Results were analyzed. Results There were 105 pathological changes in 108 patients (97.22%), of which 48 cases were G_1S_0 or G_0S_1 (44.44%), 3 cases were G_1S_0 (2.78%), 57 cases were S_2 or G_2 (52.78%) %. There was no significant difference in fibrosis stage and grade of liver inflammation between serum HBV-DNA <105copies / ml and serum HBV-DNA> 105copies / ml (P> 0.05). As age increases, the degree of fibrosis and hepatic inflammation in patients will be more and more serious. The degree of fibrosis and liver inflammation in patients> 40 years old is significantly higher than that in patients <40 years old> 40 years old The proportions of patients with S2-4 and G2-4 were significantly higher than those of patients <40 years old (P <0.05). Conclusion Patients with chronic hepatitis B virus infection may be associated with varying degrees of histopathological changes in liver tissue. However, the older the patients are, the more serious the degree of fibrosis and liver inflammation are. However, the degree of fibrosis and the degree of liver inflammation are similar to those of serum HBV-DNA No major correlation level.