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近十余年来,抗菌素得到了飞跃发展,新的品种不断增加,許多抗菌素在临床上的广泛应用起了极大的作用,但由于普遍使用和某些濫用,导致了不少耐葯性的产生,严重地影响了治疗。因此目前用二种或三种抗菌素同时治疗某一种疾病实較多見。这种联合应用抗菌素有合理与不合理之处,用之不当,非但无益,反而有害,故为当前一个需要解决的重要課题。联合应用产生的作用抗菌素和其他抗菌素或化学葯品制剂联合应用后,可以产生协同、累加、无关、拮抗等四种作用。 1.协同作用:联合应用时能互相增进功效,其
In the recent ten years, the antibiotics have made rapid development. New breeds have been increasing. Many antibiotics have played a great role in the clinical application. However, due to the widespread use and certain abuse, many antibiotics have been produced , Seriously affected the treatment. So currently with two or three antibiotics to treat a particular disease is more common. This joint application of antibiotics is reasonable and unreasonable, improper use, not only useless, but harmful, it is an important issue to be solved. The combined effect of antibiotics and other antibiotics or chemical agents combined application, can produce synergies, accumulation, irrelevant, antagonistic and other four kinds of effects. Synergy: When applied in combination can enhance each other’s effectiveness