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本研究报道克山病病区低硒儿童血小板聚集性和血栓素水平的改变以及这些改变与血硒水平的相关性,为缺硒在克山病病因和发病学中的作用提供新的依据。结果表明克山病病区低硒儿童全血硒15±9(9)ng/ml和红细胞硒(65±30(19)ng/g Hb)明显低于非病区儿童全血硒106±15(14)ng/ml和红细胞硒545±75(20)ng/gHb(P<0.01);病区低硒儿童血浆血栓素B_2(TXB_2)(148.4±76.3(18)pg/ml)明显高于非病区(83±26.3(18)pg/ml)(P<0.01);而血浆6-硐-PGF_(12)病区23.9±3.7(18)pg/ml和非病区24.6±4.4(18)pg/ml无明显差异(P>0.05);同时发现,用外源性花生四烯酸(0.5mmol/L)刺激血小板时,病区儿童血小板TXB_2的产量
The present study reports the changes of platelet aggregation and thromboxane level in selenium-deficient children and the correlation between these changes and selenium levels in Keshan disease-endemic areas, and provides a new basis for the role of selenium deficiency in the etiology and pathogenesis of Keshan disease. The results showed that selenium in children with selenium in Keshan disease was 15 ± 9 (9) ng / ml and selenium (65 ± 30 (19) ng / g Hb) (14.4 ng / ml) and red blood cell selenium (545 ± 75 (20) ng / gHb) (P <0.01). The plasma TXB 2 in the selenium-depleted children was significantly higher than that of the TXB_2 (148.4 ± 76.3) (P <0.01). However, there was no significant difference between the two groups (P> 0.05) ) pg / ml had no significant difference (P> 0.05). At the same time, when using arachidonic acid (0.5mmol / L) to stimulate platelets, the yield of TXB_2