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美《科学》杂志第207卷第4435期第1214页(1980年)载文摘:糖精与膀胱癌的关系是科学界久已争论的问题,甚至涉及立法范围与规章的制定。现有的实验和流行病学证据相互矛盾。用糖精喂词大鼠的实验研究证明膀胱癌发病率增高,具有统计学上的意义;体外及体内实验也观察到糖精有促癌作用。已发表的流行病学研究都是阴性结果,只有一项报告说增加男性患膀胱癌的危险性。本研究是对纽约一些医院中就医的病人所作的调查;包括男病人312名、女病人79名,均于入院时诊断为膀胱瘤;另设对照组,男3,798
Science, Vol. 207, No. 4435, p.1214 (1980). Abstract: The relationship between saccharin and bladder cancer has long been a controversial issue in the scientific community. It even involves the formulation of the scope and rules of legislation. Existing experimental and epidemiological evidence is contradictory. The experimental study of rats fed with saccharin showed that the incidence of bladder cancer was increased, which was statistically significant. Sweeteners were also found to have carcinogenic effects in vitro and in vivo. Published epidemiological studies are negative results, only one report said men increase the risk of bladder cancer. This study was conducted on patients admitted for medical treatment in some hospitals in New York City; 312 male patients and 79 female patients were diagnosed with bladder cancer on admission; another control group, male 3,798