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本文对35例儿童急性淋巴细胞白血病(ALL)患者,测定了治疗前每例骨髓200个细胞的细胞面积。作者认为细胞面积的测定比细胞直径更好,并规定多于12微米者为大原始淋巴细胞(MLB)。患者年龄在4(1/2)～11(1/2)岁之间。诱导缓解用长春新碱,强的松和柔红霉素。在缓解初期用长春新碱和强的松进行再诱导,6个月后用联合化学治疗。这些病人在治疗前观察骨髓选择一个细胞没有重叠和形态完整的区域,放在显微镜下放大1250倍,用面积公式=πr~2以圆形面积表示,从而计算其细胞直径,细胞直径>12微米者为大原始淋巴细胞,根据大原始淋巴细胞百分数的多少分为两组。1组MLB≤25%,Ⅰ组MLB>25%,另外在每个病人诊断时确定了危险因素的数量,下列标准之一被认为是危险因素;①白细胞数大于10万/立方毫米,②纵膈
In this study, 35 patients with acute lymphoblastic leukemia (ALL) were measured for the area of 200 cells per bone marrow before treatment. The authors believe that the determination of cell area is better than the cell diameter and stipulates that more than 12 micrometers are large primitive lymphocytes (MLB). Patients were between 4 (1/2) and 11 (1/2) years of age. Induced remission with vincristine, prednisone and daunorubicin. In the initial period of remission, vincristine and prednisone were used for reinduction, and after 6 months combined chemotherapy was used. These patients were observed before treatment bone marrow selection of a cell without overlapping and morphological integrity of the area, zoom in under a microscope 1250 times, with the area formula = πr ~ 2 in a circular area to calculate the cell diameter, cell diameter >12 microns Large primary lymphocytes were divided into two groups according to the percentage of large primary lymphocytes. 1 group of MLB≤25%, group I MLB>25%, and the number of risk factors was determined in each patient’s diagnosis. One of the following criteria was considered to be a risk factor; 1 white blood cell count was greater than 100,000/mm 3 , 2 longitudinal diaphragm