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目的：单光子发射计算机断层（ｓｉｎｇｌｅｐｈｏｔｏｎｅｍｉｓｉｏｎｃｏｍｐｕｔｅｄｔｏｍｏｇｒａｐｈｙ，ＳＰＥＣＴ）核素骨显像在显示骨病变方面有很高的灵敏度，而对病变性质的判断缺少定量的手段，因此有必要寻找一种放射性核素骨显像中鉴别病变性质的简便、有效的判断方法，应用感兴趣区（ＲｅｇｉｏｎｏｆＩｎｔｅｒｅｓｔ，ＲＯＩ）技术对骨病变进行分析，以期建立一种可靠的方法。方法：根据“临床核医学检查规程”行全身、局部及断层骨显像及２４ｈ延迟显像，应用ＲＯＩ处理技术，选定ＲＯＩ进行处理，计算病灶及正常对照区的２４ｈ／４ｈ的比值，采用ｔ检验处理。结果：共发现３１８个病灶，放射性增高区２８５个，恶性病变与良性病变比较，差异具高度显著性；放射性减低区病灶３３个，良性骨病变与恶性病变比较，比值均高，其差异具高度显著性。结论：应用ＲＯＩ技术所得结果根据其比值可在相当程度上区别放射性增高病灶的良恶性，而放射性减低的恶性病灶其意义有待进一步探讨。
OBJECTIVE: Single photon emission computed tomography (SPECT) radionuclide bone imaging has a high sensitivity in the detection of bone lesions, while the quantitative determination of the nature of the disease is lack of quantitative means. Therefore, it is necessary to find a radionuclide bone was significantly Like the simple and effective method of identifying the nature of the lesion, using the Region of Intensity (ROI) technique to analyze the bone lesions to establish a reliable method. Methods: According to the “Rules of Clinical Nuclear Medicine”, we performed whole-body, partial and sectional bone imaging and delayed imaging for 24h, and applied ROI to select ROI for treatment. The ratio of lesions to normal control area was calculated at 24h / 4h. t test treatment. Results: A total of 318 lesions were found, and 285 were radioactive hyperplasia. There was a significant difference between malignant lesions and benign lesions. There were 33 lesions with reduced radioactivity, and the ratios of benign bone lesions to malignant lesions were higher than those with benign lesions Significance. Conclusion: The results of ROI technique can distinguish the benign and malignant lesions of radioactive increase to a certain extent according to the ratio of ROI. However, the significance of radiological reduction of malignant lesions needs to be further explored.