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目的:通过一个新型造模为骨折延迟愈合的研究提供新思路。方法:选雌大鼠24只,随机分为A和B组,每组12只,A组麻醉后结扎股动脉,用冲撞法制作股骨骨折模型;B组麻醉后用冲撞法制作股骨骨折模型。分别于1,4及8周后观察大体标本、骨痂形态、X线检查确定骨折延迟愈合模型形成情况。结果:大体标本肉眼观察、骨组织形态学检查及放射学检查均显示A组骨缺损区骨愈合较B组慢,A组骨性连接出现较晚,骨端硬化。结论:本实验所建立的动物模型,具有缺血性骨折延迟愈合的病理改变,与缺血性骨折延迟愈合的发生机制相符,符合缺血性骨折延迟愈合模型的要求,故可以认为是一种可靠的实验性缺血性骨折延迟愈合动物模型。
OBJECTIVE: To provide a new idea through a new type of modeling for the study of delayed union of fractures. Methods: Twenty-four female rats were randomly divided into groups A and B, with 12 rats in each group. A group was anesthetized and femoral artery was ligated. The femur fracture model was made by collision method. B group was made into the femur fracture model by collision method after anesthesia. After 1, 4 and 8 weeks respectively, the gross specimens, callus morphology and X-ray examination were used to confirm the formation of delayed union model. Results: The macroscopic observation, bone histomorphology and radiological examination showed that the bone healing in group A was slower than that in group B, and that in group A was later than that in group B, and bone sclerosis was found in group A. Conclusion: The animal model established in this experiment has the pathological changes of delayed union of ischemic fracture, which is consistent with the mechanism of delayed union of ischemic fracture and meets the requirement of delayed union model of ischemic fracture, so it can be considered as a Reliable experimental ischemic fracture delayed healing in animal models.