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本文作者通过输尿管用冷杯活检术取得膀胱癌标本46例,29例用直接法制片,第30例用3天短期培养法,都具有适当的中期分裂相。每一例最少计数4个中期分裂相,最多计数24个。22例进行了染色体显带分析,结果发现在膀胱癌中存在染色体数目和结构畸变,其中19例存在异常克隆(按Rowely标准,鉴定克隆异常,即用显带技术确定至少有两个细胞具有相同的额外染色体或结构重排,或三个细胞都丢失了同一个染色体),主要涉及1号、3号、及11号染色体的改变(分别是36.6%、26.6%、20%)其次是4号、7号、及18号(均为10%)。结
The authors obtained 46 cases of bladder cancer specimens by ureteral cold cup biopsy, 29 cases with direct method and 30 cases with 3-day short-term culture method, all with appropriate metaphase. For each case, a minimum of 4 metaphase counts should be counted up to a maximum of 24 counts. Twenty-two of the 22 cases had chromosome banding analysis and found that there were chromosomal number and structural aberrations in bladder cancer. Of the 19 cases, there were abnormal clones (According to Rowely standard, clonal abnormalities were identified, that is, banding technique was used to determine that at least two cells were the same (Or 36.6%, 26.6%, and 20%, respectively) of chromosomes 1, 3, and 11, followed by chromosome 4 (the number of extra chromosomes or structural rearrangements, or the loss of the same chromosome in all three cells) , 7 and 18 (both 10%). Knot