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采用细胞计数法、3~H-胸腺嘧啶核苷掺入法测试了血栓通、汉防已甲素及黄连素等中药对兔皮肤纤维母细胞的抑制作用。结果表明前两种药物对兔皮肤纤维母细胞的增殖具有显著的抑制作用,血栓通的50％抑制剂量(ID_(50))为100mg/L,汉防己甲素的ID_(50)为3.7mg/L。目的在于为增殖性玻璃体视网膜病变的药物治疗寻找新的药源。
Cell counting and 3H-thymidine incorporation were used to test the inhibitory effects of Chinese medicines such as Xueshuantong, chlorpromazine and berberine on rabbit skin fibroblasts. The results showed that the first two drugs had a significant inhibitory effect on the proliferation of rabbit skin fibroblasts. The 50% inhibitor (ID_(50)) of thromboxane was 100 mg/L and the ID_(50) of tetrandrine was 3.7 mg. /L. The aim is to find new sources of drugs for the treatment of proliferative vitreoretinopathy.