曾报道,生长激素(GH)、胰岛素和胰岛素样生长因子-I(IGF-I)能调节颗粒细胞成熟,但其作用机理尚未充分阐明。Hutchinson 等研究了 GH、IGF-I 和卵泡刺激素(FSH)间相互作用的性质,以及它们对颗粒细胞甾体生成作用的影响。实验所用颗粒细胞取自己烯雌酚处理的未成熟大鼠,在离体条件下再用孕马血清促性腺激素(PMSG)或 FSH 加以刺激。结果表明,GH 在 PMSG 存在下,能增加芳香化酶活性和孕酮 It has been reported that growth hormone (GH), insulin, and insulin-like growth factor-I (IGF-I) regulate granulosa cell maturation, but its mechanism of action has not yet been fully elucidated. Hutchinson et al. Studied the nature of the interactions between GH, IGF-I and follicle-stimulating hormone (FSH) and their effect on the production of granulosa cells. Granular cells used in the experiment were taken from diethylstilbestrol-treated immature rats and stimulated with pregnant mare serum gonadotropin (PMSG) or FSH ex vivo. The results show that GH can increase aromatase activity and progesterone in the presence of PMSG