论文部分内容阅读
目的了解新疆地区艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)合并感染丙型肝炎病毒(HCV)状况及其影响因素。方法收集新疆地区12家国家免费抗病毒治疗中心,2005-2011年收治的HIV/AIDS病人抗病毒治疗前的临床资料,并进行回顾性分析。采用多因素Logistic回归分析HIV/HCV合并感染的影响因素。结果 2357例HIV/AIDS病人中,HCV合并感染率为38.0%(895/2357)。在经静脉吸毒途径感染HIV者中,HCV合并感染率为77.5%(678/875);经异性性途径感染HIV者中为11.7%(122/1042),经同性性途径感染HIV者中为21.0%(21/100),其他途径感染HIV者(输血传播、母婴传播等)HCV合并感染率为21.8%(74/340)。2005-2011年,年均HIV/HCV合并感染率由51.1%下降至25.2%(P<0.01),按HIV感染途径进行分层后,年均HIV/HCV合并感染率在各层中变化差异无统计学意义(P>0.05)。多因素Logistic回归分析结果显示,地区、年龄、性别及HIV感染途径与HIV/HCV合并感染相关,而民族及CD+4T淋巴细胞计数与HIV/HCV合并感染无关。HIV/HCV合并感染者中,血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平高于正常检测值上限2.5倍者(100U/L)的比例,高于HIV单纯感染者,差异有统计学意义(P<0.01)。结论新疆地区HIV/AIDS病人中HCV感染率较高,尤其是在静脉注射吸毒者中合并感染率更高。应采取积极措施防止HIV、HCV的合并感染及传播。对HIV/HCV合并感染者,应重视防治由病毒性肝炎导致的肝脏损害。
Objective To investigate the status of hepatitis C virus (HCV) infection and its influencing factors in HIV / AIDS patients in Xinjiang (referred to as HIV / AIDS patients). Methods The free antiviral treatment centers in 12 countries in Xinjiang were collected and the clinical data of HIV / AIDS patients treated before 2005-2011 were retrospectively analyzed. Multivariate logistic regression analysis was used to analyze the influencing factors of HIV / HCV co-infection. Results Among 2357 HIV / AIDS patients, the infection rate of HCV was 38.0% (895/2357). HCV co-infection rates were 77.5% (678/875) among those infected with intravenous drug use, 11.7% (122/1042) among those infected with the heterosexual route, and 21.0% among those infected with the homosexual route % (21/100). The infection rate of HCV in other routes of infection (blood transfusion, mother-to-child transmission, etc.) was 21.8% (74/340). From 2005 to 2011, the annual average HIV / HCV co-infection rate dropped from 51.1% to 25.2% (P <0.01). After stratified by HIV infection, the annual average HIV / Statistical significance (P> 0.05). Multivariate logistic regression analysis showed that regional, age, gender and HIV infection were associated with HIV / HCV co-infection, while ethnic and CD + 4T lymphocyte counts were not associated with HIV / HCV co-infection. Among HIV / HCV co-infected patients, the serum ALT and AST levels were higher than those of 2.5 times the normal upper limit (100U / L) The difference was statistically significant (P <0.01). Conclusion The HCV infection rate among HIV / AIDS patients in Xinjiang is high, especially in the case of intravenous drug users. Proactive measures should be taken to prevent co-infection and transmission of HIV and HCV. HIV / HCV co-infection, attention should be paid to the prevention and treatment of liver damage caused by viral hepatitis.