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目的观察并分析高通量血液透析对严重肾衰竭患者的治疗效果。方法将76例严重肾衰竭患者随机平均分为高通量透析组和常规透析组两组,分别进行高通量透析或常规透析治疗,疗程为3个月。治疗结束后分析其疗效,并观察患者的临床表现、体征的改善情况和生化指标的变化情况。结果经3个月治疗后,高通量透析组患者的总有效率为78.9%,而常规透析组的为55.3%,两者间差异存在统计学意义。两组治疗前各项检测指标差异无统计学意义。经治疗3个月后,高通量透析组的β2-MG、Scr、BUN、24 h尿蛋白、Hb与治疗前比较差异有统计学意义(P<0.05),而A lb未见显著改变(P>0.05)。常规透析组的β2-MG、Scr、BUN、A lb、24 h尿蛋白、Hb均与治疗前存在显著性差异。组间比较,高通量透析组的β2-MG、24 h尿蛋白、Hb与常规透析组比较差异存在统计学意义(P<0.05)。而且高通量透析组的不良反应也较常规透析组的为轻。结论高通量血液透析可有效治疗并改善严重肾衰竭患者的情况。
Objective To observe and analyze the therapeutic effect of high-flux hemodialysis on patients with severe renal failure. Methods A total of 76 patients with severe renal failure were randomly divided into two groups: high-flux dialysis group and conventional dialysis group. High-throughput dialysis or routine dialysis was performed respectively for 3 months. After the treatment, the curative effect was analyzed and the clinical manifestations, signs and symptoms of the patients and the changes of the biochemical indexes were observed. Results After 3 months of treatment, the total effective rate in high-throughput dialysis group was 78.9%, compared with 55.3% in conventional dialysis group, the difference was statistically significant. There was no significant difference between the two groups before treatment. After 3 months of treatment, β2-MG, Scr, BUN, 24 h urinary protein and Hb in high-throughput dialysis group were significantly different from those before treatment (P <0.05) P> 0.05). Conventional dialysis group β2-MG, Scr, BUN, A lb, 24 h urine protein, Hb were significantly different from before treatment. There were significant differences between the two groups (P <0.05). There was significant difference between high-throughput dialysis group in β2-MG, 24 h urine protein, Hb and routine dialysis group. And high-throughput dialysis group adverse reactions than the conventional dialysis group is light. Conclusion High-throughput hemodialysis can effectively treat and improve the patients with severe renal failure.