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目的对牡荆素急性毒性进行研究,为牡荆素制剂临床应用提供安全依据。方法将牡荆素配成30 mg/ml的溶液给药,按照50%递增法给药体积依次设计为2.0、3.0、4.5、6.8、10.1、15.2 ml/kg一系列剂量组进行实验。结果 Beagle犬接受单剂量牡荆素后出现呕吐反应,随着给药剂量的递减呕吐频率和程度减轻;牡荆素犬无毒反应剂量为204 mg/kg,出现呕吐反应的剂量为303 mg/kg,单次最大给药量为600 mg/kg;剖检观察期结束后存活的犬,各主要脏器均未发现有肉眼可见的病理改变。结论牡荆素急性毒性研究在安全剂量内使用安全。
Objective To study the acute toxicity of vitexin and provide the safety basis for the clinical application of vitexin preparation. Methods Vitexin was dosed as a solution of 30 mg / ml. The dosage of vitexin was designed to be 2.0, 3.0, 4.5, 6.8, 10.1 and 15.2 ml / kg according to the 50% increment method. Results The vomiting reaction of Beagle dogs after receiving single dose of vitexin was relieved with the decrease of the dose and the degree of vomiting. The dose of vitexin was 204 mg / kg and the dose of vomiting was 303 mg / kg, a single maximum dose of 600 mg / kg; necropsy observation after the end of the dog, all the major organs were not found with macroscopic pathological changes. Conclusion Vitexin acute toxicity study is safe to use in safe dose.