论文部分内容阅读
目的：本研究旨在了解大剂量山莨菪碱及地塞米松对兔多器官功能障碍时对肿瘤坏死因子（TNF）、脂质过氧化物（LPO）的影响。以探讨MODS时抗细胞因子、抗氧自由基治疗的新途径。方法：本实验首先将日本大耳兔行盲肠结扎加穿孔（CLP）造成腹腔感染致MODS的动物模型，随机分为山莨菪碱组、地塞米松组、大剂量山莨菪碱及地塞米松组、对照组，静脉应用相应药物后，分别于3、7、24h抽血测定，观察TNF、LPO的变化。结果：TNF、LPO的变化：山莨菪碱组、地塞米松组和山莨宕碱及地塞米松联合用药组血浆的TNF、LPO水平均有明显的降低，P值＜0．01，联合用药组最突出。联合用药组与单用山莨菪碱或地塞米松组亦有显著的差别。结论：山莨菪碱和地塞米松能明显抑制兔在MODS时TNF、LPO的水平，特别是联合应用大剂量山莨菪碱及地塞米松尤为明显。提示大剂量山莨菪碱及地塞米松联合应用可能是MODS时抗细胞因子、抗氧自由基治疗的一种新途径。
Objective: This study aimed to understand the effects of high dose of anisodamine and dexamethasone on tumor necrosis factor (TNF) and lipid peroxides (LPO) in rabbits with multiple organ dysfunction. To explore MODS anti-cytokine, antioxidant free radical treatment of new ways. Methods: The animal model of MODS induced by peritoneal infection caused by cecal ligation and perforation (CLP) in Japanese big-eared rabbits was randomly divided into three groups: Anisodamine group, dexamethasone group, high-dose Anisodamine group and dexamethasone group , The control group, intravenous application of the corresponding drug, respectively, at 3,7,24h blood test to observe the changes of TNF, LPO. Results: The changes of TNF and LPO: The levels of plasma TNF and LPO in anisodamine group, dexamethasone group and anisodamine and dexamethasone group were significantly lower than those in control group (P <0.01) The most prominent group. Combination therapy group and anisodamine alone or dexamethasone group also have significant differences. Conclusion: Anisodamine and dexamethasone can significantly inhibit the levels of TNF and LPO in rabbits during MODS, especially for combination of high dose of anisodamine and dexamethasone. Prompted high-dose combination of anisodamine and dexamethasone may be MODS anti-cytokine, a new approach to the treatment of antioxidant free radicals.