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法莫替丁(famotidine)是一种含有脒丙基噻唑环的长效强力 H_2受体阻滞剂,作用较西米替丁强20～160倍,较雷尼替丁强3～20倍;抑制分泌的作用时间也较西米替丁和雷尼替丁长,服用法莫替丁10mg之后,其抑制分泌作用可持续12h 以上。现已证实法莫替丁是一种安全可靠的新型长效 H_2受体阻滞剂.方法本文以双盲随机安慰剂对照的方法,对384例活动性十二指肠溃疡进行对照研究。全部患者均经内窥镜确诊,溃疡直径为0.5～2.5cm.随机分为4组:第1组,早晨服安慰剂一次,睡前服法莫替丁
Famotidine is a long-acting potent H_2 receptor blocker containing amidin propylthiazole, which is 20 ~ 160 times more potent than cimetidine and 3 ~ 20 times stronger than ranitidine. Inhibition of secretion of time than cimetidine and ranitidine longer, taking famotidine 10mg, the inhibition of secretion of sustainable 12h or more. It has been demonstrated that famotidine is a safe and reliable new long-acting H 2 receptor blocker.Methods 384 patients with active duodenal ulcer were studied in a double-blind randomized placebo-controlled trial. All patients were confirmed by endoscopy, ulcer diameter of 0.5 ~ 2.5cm. Randomly divided into 4 groups: group 1, morning placebo placebo, famotidine