报告慢性进行性放射性脊髓病4例，1例为鼻咽癌放疗后，3例为食管癌放疗后。其临床特征是：疼痛，上下肢感觉障碍于运动障碍，进而至截瘫；其发病与病人存活时间、脊髓受照长度、脊髓受照节段、受照剂量，以及射线的个体敏感度等因素相关；MRI有助于本病的诊断与预后的评价。其预后差，死亡率高；治疗应以综合措施为主，本病重在预防。 4 cases of chronic progressive radiation-induced spinal cord disease, 1 case of nasopharyngeal carcinoma after radiotherapy, 3 cases of esophageal cancer after radiotherapy. Its clinical features are: pain, upper and lower extremity sensory disturbances in dyskinesias, and then to paraplegia; its incidence and patient survival time, spinal cord length of irradiation, spinal cord segments, exposure dose, and individual sensitivity to radiation and other factors ; MRI contribute to the diagnosis of the disease and prognosis evaluation. The prognosis is poor, high mortality; treatment should be based on comprehensive measures, the disease is focused on prevention.