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妊娠及促孕雄激素对生育活跃期妇女突发的播散性红斑狼疮(LED)的进展有不良影响,对伴有Klinefelter综合征(先天性睾丸发育不全症)的LED男性者患者LED的发病率亦有影响,因而认为在这种多病因疾病的临床表现中有性激素的参预。在几组鼠的实验中一致证明雌激素对鼠的狼疮有加重的影响,而雄激素则起保护作用。曾有报告在LED女性患者尿中雌激素成分异常,染色体组正常的男性患者血浆中雄激素/雌激素的比值降低亦有记
Pregnancy and pregnancy-androgen-induced adverse effects on the development of sudden-onset diffuse lupus erythematosus (LED) in women of reproductive development, the incidence of LED in patients with LED in Klinefelter syndrome (congenital testicular hypoplasia) Rates also have implications and therefore suggest that sexual hormones are involved in the clinical presentation of this multi-etiological disease. Several groups of mice in the experiment unanimously proved that estrogen has a heavier impact on rat lupus, while androgens play a protective role. There have been reports of LED female patients with abnormal urinary estrogen composition, genomic male patients with normal plasma levels of androgen / estrogen reduction also recorded