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目的:了解日达仙的免疫调节作用。方法:选取18例重型肝炎病人用日达仙(Tα_1)治疗,并在治疗前后检测内毒素(LSP)、肿瘤坏死因子(TNF)、白细胞介素2受体(IL-2R)、白细胞介素4(IL-4)、白细胞介素6(IL-6),及T细胞亚群(CD_8~+、CD_4~+)。结果:治疗前LSP、TNF、IL-2R、IL-6、CD_8~+增高(P<0.01),而IL-4及CD_4~+降低。经Tα_1治疗后,LSP、TNF、IL-2R、IL-6、CD_8~+均降低(P<0.01),而IL-4和CD_4~+增高。结论:Tα_1是一种强有力的免疫调节剂,它能降低LSP、TNF、IL-2R、IL-6、CD_8~+,提升IL-4水平,从而减轻重型肝炎时免疫反应对肝细胞的损伤。
Objective: To understand the immune regulation role of Zadaxin. Methods: Eighteen patients with severe hepatitis were treated with Tα_1, and the levels of endotoxin (LSP), tumor necrosis factor (TNF), interleukin 2 receptor (IL-2R), interleukin IL-4, IL-6 and CD_4 ~ + of T cell subsets. Results: Before treatment, the levels of TNF, IL-2R, IL-6 and CD_8 + increased (P <0.01), while the levels of IL-4 and CD_4 decreased. After Tα_1 treatment, the levels of LSP, TNF, IL-2R, IL-6 and CD_8 + decreased (P <0.01) and IL-4 and CD_4 + increased. Conclusion: Tα_1 is a potent immunomodulatory agent that can reduce the levels of IL-4, LSP, TNF, IL-2R, IL-6 and CD_8 +, thereby reducing the damage of hepatocytes caused by immune response in severe hepatitis .