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对于高血压心得安可单独用作第一步的治疗药,但它常与噻嗪类利尿剂联合作为第二步治疗。哌唑嗪(prazosin)是一种选择性作用于突触后的α-肾上腺素能阻滞剂,常与利尿剂联合作为第二或三步治疗原发性高血压。作者曾证明,甲基多巴加双氢克尿噻不能适当控制的高血压改用哌唑嗪加利尿剂则有效。本文将研究哌唑嗪与哌唑嗪加心得安对用双氢克尿噻加心得安治疗无效的高血压患者的疗效。作者将14名用双氢克尿塞(50mg/d)加心得安(240mg/d)治疗血压都未能控制(坐位舒张压≥95mmHg)的男性高血压患者(年龄45～70岁,平均59岁)分成两组。最初4周观察期间,患者都一直接受
Anke is used as a first-line treatment for hypertension, but it is often combined with thiazide diuretics as a second-step treatment. Prazosin is a selective post-synaptic alpha-adrenergic blocker often associated with diuretics as a second or third step in the treatment of essential hypertension. The authors have shown that methadopa and hydrochlorothiazide can not properly control the hypertension to prazosin plus diuretics is effective. This article will study the effect of prazosin and prazosin plus propranolol in patients with hypertensive patients treated with hydrochlorothiazide plus propranolol. The authors divided 14 male hypertensive patients (aged 45-70 years, mean age 59 years) with two hydrochlorothiazide (50 mg / d) plus propranolol (240 mg / d) in treatment BP (sitting diastolic pressure ≥95 mmHg) group. During the first 4 weeks of observation, the patient has been accepted