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目的评价中西医结合治疗糜烂型口腔扁平苔藓(orallichenplanus,OLP)的临床疗效。方法选择2008年2月至2010年6月在江西省抚州市第一人民医院口腔科就诊的86例糜烂型OLP患者,随机分为试验组和对照组,各43例。试验组采用局部注射曲安奈德配合中药治疗,对照组仅局部注射曲安奈德。分别对两组患者治疗前、治疗1个月后和治疗6个月后的局部病损进行分级评定,并进行对比观察。结果治疗1个月后试验组和对照组有效率分别为83.33%和83.72%,两组比较,差异无统计学意义(χ2=0.002,P=0.962);治疗6个月后试验组有效率为76.68%,优于对照组的26.32%,差异有统计学意义(χ2=17.053,P<0.001)。结论中西医结合治疗糜烂型OLP的疗效优于单纯的局部注射治疗。
Objective To evaluate the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of erosive oral lichen planus (OLP). Methods From February 2008 to June 2010, 86 patients with erosive OLP treated in Department of Stomatology, First People’s Hospital of Fuzhou, Jiangxi Province were randomly divided into experimental group and control group, with 43 cases in each group. The experimental group was treated with local injection of triamcinolone acetonide in combination with traditional Chinese medicine, while the control group received only local injection of triamcinolone acetonide. The local lesions of two groups before treatment, one month after treatment and six months after treatment were graded and compared. Results After 1 month of treatment, the effective rates of the experimental group and the control group were 83.33% and 83.72% respectively. There was no significant difference between the two groups (χ2 = 0.002, P = 0.962). After 6 months of treatment, the effective rate of the experimental group was 76.68%, which was better than 26.32% of the control group, the difference was statistically significant (χ2 = 17.053, P <0.001). Conclusion Integrative treatment of erosive OLP is better than the simple injection of local treatment.