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二个独立的研究小组将猴肉瘤病毒内发现的sis致癌基因与人血中为血小板衍生的生长因子(PDGF)所编码的基因联系起来。圣迭戈加利福尼亚大学的Russell Doolittle说,在已知的PDGF多肽片段的70个氨基酸中,有87％与致癌基因产物序列的氨基酸一致。虽然不完全一致,但极为接近。百分比的差别是由于种属差异,原在预料中。迄今,仍不了解任何一种致癌基因对细胞生长和分化有何特异性影响。以上发现是首次证明致癌基因的产物是一种蛋白质,并了解到它对正常细胞具有生理学作用。
Two independent research groups linked the sis oncogene found in monkey sarcoma virus with the gene encoded by platelet-derived growth factor (PDGF) in human blood. Russell Doolittle of the University of California, San Diego, says that of the 70 amino acids of the known PDGF polypeptide fragment, 87% are identical to the amino acids of the oncogene product sequence. Although not exactly the same, it is extremely close. The difference in percentage is due to species differences and was originally expected. To date, it is still unknown what specific effects any of the oncogenes have on cell growth and differentiation. The above findings are the first to prove that the product of the oncogene is a protein and that it has a physiological effect on normal cells.