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目的观察亮菌口服液在结核病治疗中预防药物肝损害的疗效。方法 86例肺结核患者随机分为两组:治疗组在采取抗结核方案基础上应用亮菌口服液,对照组仅采取与治疗组相同的抗结核方案,观察两组肝功能损害情况。结果治疗组发生肝功能异常的比例及停用抗结核药物后肝功能恢复正常的平均时间均低于对照组(P<0.05)。结论抗结核治疗的同时应用亮菌口服液可以降低肝损害的发生率,发生肝损害的程度也可减轻,不良反应较少。
Objective To observe the efficacy of Liangbai Oral Liquid in the prevention of liver damage in the treatment of tuberculosis. Methods Totally 86 patients with tuberculosis were randomly divided into two groups: the treatment group was treated with Liangbai Oral Liquid on the basis of anti-TB regimen, while the control group only received the same anti-TB regimen as the treatment group. The liver function impairment was observed in both groups. Results The proportion of liver dysfunction in treatment group and the average time of normal liver function recovery after antituberculosis drug withdrawal were lower than those in control group (P <0.05). Conclusion The application of Liangbi oral solution can reduce the incidence of liver damage and reduce the degree of liver damage, with fewer adverse reactions.