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目的探讨核黄素强化盐对食管癌高发区居民食管癌的预防效果,为进一步推广其应用提供现场依据。方法将河北省磁县固义乡21个村所有居民分为干预组和对照组,从2000年开始,干预组服用核黄素强化盐(核黄素100～150mg/kg);对照组服用未添加核黄素的普通盐。随机抽取干预组和对照组40～69岁组各250人测定其血液中红细胞谷胱甘肽还原酶活性系数(EGRAC),评价核黄素营养状况。通过磁县肿瘤登记处进行随访,监测两组人群食管癌发病情况。结果核黄素强化盐干预8年后,干预组EGRAC平均值为1.383,低于对照组1.532,且差异有统计学意义(P﹤0.01);干预组2003～2008年共发生食管癌90例,年发病率为131.79/10万,对照组共发生食管癌80例,年发病率为137.30/10万,干预组稍低于对照组,但差异未显示出统计学意义。结论核黄素强化盐能显著改善人体核黄素营养状况,是经济、简便和有效的营养干预手段。
Objective To investigate the preventive effect of riboflavin fortified salt on esophageal cancer in residents with high incidence of esophageal cancer and provide a field basis for further application. Methods All residents of 21 villages in Guyi Township, Cixian County, Hebei Province were divided into intervention group and control group. From 2000, the intervention group took riboflavin enhanced salt (riboflavin 100 ~ 150 mg / kg) Add common salt of riboflavin. Randomly select the intervention group and the control group of 40 to 69-year-old group of 250 people to determine the erythrocyte glutathione reductase activity coefficient (EGRAC), evaluation of riboflavin nutritional status. Through the Cixian Cancer Registry for follow-up, the incidence of esophageal cancer in both groups was monitored. Results The average value of EGRAC in the intervention group was 1.383 after eight years of intervention with riboflavin, which was significantly lower than that in the control group (P <0.01). There were 90 cases of esophageal cancer in the intervention group from 2003 to 2008, The annual incidence rate was 131.79 / 100 000. There were 80 cases of esophageal cancer in the control group, the annual incidence was 137.30 / 100 000, the intervention group was slightly lower than the control group, but the difference did not show statistical significance. Conclusion Riboflavin enhanced salt can significantly improve the human riboflavin nutritional status, is an economical, simple and effective means of nutritional intervention.