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目的 观察尼尔雌醇替代治疗对绝经后妇女血脂及血液流变学的影响。 方法 对 36例绝经后妇女用尼尔雌醇进行替代治疗 ,剂量为每半月 2mg ,共 6月 ,最后 7d加用安宫黄体酮 8mg·d-1,于用药前和治疗 6月后分别测血脂及血液流变学指标。 结果 尼尔雌醇替代治疗 6月后血总胆固醇 (TC)、低密度脂蛋白胆固醇(LDL C)、TC/高密度脂蛋白胆固醇 (HDL C)、LDL C/HDL C均明显下降 (P <0 0 1) ,HDL C明显升高 (P <0 0 1) ,血纤维蛋白原 (PFC)、全血粘度 (ηb)、血浆粘度 (ηp)、细胞压积 (HCT)均显著下降 (P <0 0 1) ,血液还原粘度 (ηr)明显下降(P <0 0 5 )。 结论 用尼尔雌醇替代治疗能明显改善血脂紊乱 ,降低血粘度。
Objective To observe the effects of nile estrogen replacement therapy on blood lipids and hemorheology in postmenopausal women. Methods 36 cases of postmenopausal women with nilestriol replacement therapy, the dose of 2mg every two months, a total of 6 months, the last 7d plus escitalopram 8mg · d-1, before treatment and after 6 months of treatment were measured Blood lipids and blood rheology indicators. Results The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL C), TC / HDL C and LDL C / HDL C were significantly decreased after Nilestriol replacement therapy for 6 months (P < HDL C was significantly increased (P 0 01), PFC, ηb, ηp and HCT were significantly decreased (P <0 0 1), blood viscosity (ηr) decreased significantly (P <0 0 5). Conclusion The treatment with nylestriol can obviously improve the dyslipidemia and reduce the blood viscosity.