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为探讨山东慢型克山病与柯萨奇 B 组病毒的关系,用缺口平移法制备生物素标记 CoxB_3病毒的 cDNA 探针与慢型克山病14例尸检心肌组织及10例脑外伤,CO 中毒等意外死亡的正常成人心肌组织及10例非病区7～8个月引产胎儿的心肌组织切片进行原位杂交,14例慢克中有9例检测到柯萨奇 B 组病毒的 RNA,阳性率达64%,而对照组均为阴性。提示柯萨奇 B 组病毒感染可能是山东慢型克山病发病因素之一。
To investigate the relationship between chronic Keshan disease and Coxsackie B virus in Shandong province, cDNA probes encoding biotin-labeled CoxB_3 virus and 14 cases of chronic Keshan disease autopsy myocardium and 10 cases of traumatic brain injury and CO Poisoning and other accidental death of normal adult myocardial tissue and 10 cases of non-ward 7 to 8 months fetus fetus myocardial tissue sections for in situ hybridization, 9 cases of chronic gram in 9 cases detected Coxsackie B virus RNA, The positive rate of 64%, while the control group were negative. Tip Coxsackie B virus infection may be one of the pathogenesis of chronic Keshan disease in Shandong.