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目的研究分析10名健康志愿者静脉滴注奥美拉哇的药代动力学和临床药效学情况。方法药动学参数测定采用HPLC方法,并对胃内酸抑制情况进行计算以确定奥美拉唑药效。结果奥美拉唑药时曲线符合二室开放模型,10名受试者基础胃酸都能在一定程度上受到抑制。结论结果表明静脉滴注80mg奥美拉唑可显著抑制胃酸分泌,缓解胃酸过多。
Objective To study the pharmacokinetics and clinical pharmacodynamics of Omeralla in 10 healthy volunteers. Methods Pharmacokinetic parameters were determined by HPLC method, and the gastric acid suppression was calculated to determine the efficacy of omeprazole. The results of omeprazole drug curve in line with the two-compartment open model, 10 subjects basic gastric acid can be inhibited to some extent. Conclusion The results show that intravenous infusion of 80mg omeprazole can significantly inhibit gastric acid secretion, relieve hyperacidity.