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目的 了解端粒酶活性在口腔鳞状细胞癌中的表达情况 ,并探讨端粒酶活性在口腔鳞状细胞癌演变过程中的作用。方法 对 37例口腔鳞状细胞癌、40例口腔良性肿瘤及12例正常口腔组织 ,采用聚合酶链反应 酶联免疫吸附法检测其端粒酶活性。结果 口腔鳞状细胞癌组的端粒酶活性阳性率明显高于良性肿瘤组和正常组织组。结论 端粒酶可稳定染色体末端的端粒结构 ,端粒酶活化在口腔肿瘤恶变过程中起了重要作用 ;端粒酶可作为判断癌变能力的良好分子生物学标志
Objective To understand the expression of telomerase activity in oral squamous cell carcinoma and to explore the role of telomerase activity in the evolution of oral squamous cell carcinoma. Methods The telomerase activity of 37 cases of oral squamous cell carcinoma, 40 cases of benign oral tumors and 12 cases of normal oral tissues were determined by polymerase chain reaction and enzyme-linked immunosorbent assay. Results The positive rate of telomerase activity in oral squamous cell carcinoma group was significantly higher than that in benign tumor group and normal tissue group. Conclusion Telomerase can stabilize the telomere structure at the end of the chromosome. Activation of telomerase plays an important role in the malignant process of oral tumors. Telomerase can be used as a good molecular biological marker to determine the ability of canceration.