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目的:测定冠心病患者血浆Jagged1与血管内皮生长因子(VEGF)水平,分析二者的关系并探讨其临床意义.方法:采用酶联免疫吸附法测定85例冠心病患者(稳定性心绞痛30例、不稳定性心绞痛29例、急性心肌梗死26例)以及30例对照(冠状动脉造影未见异常)血浆Jagged1和VEGF水平,并分析Jagged1与VEGF的关系.结果:稳定性心绞痛组、不稳定性心绞痛组和急性心肌梗死组血浆Jagged1和VEGF水平均高于对照组,且血浆Jagged1和VEGF的水平在稳定性心绞痛组、不稳定性心绞痛组和急性心肌梗死组逐渐升高(P均＜0.05).冠心病患者血浆Jagged1与VEGF水平呈正相关(r=0.708,P＜0.01).结论:Jagged1与冠心病关系密切.“,”Aim:To investigate the plasma levels of Jagged1 and vascular endothelial growth factor(VEGF) in the patients with coronary heart disease (CHD),and to analyze the relationship and clinical significance between Jagged1 and VEGF.Methods:The plasma levels of Jagged1 and VEGF in CHD patients(n =85) and healthy controls(n =30) were measured by ELISA.The patients with CHD were allocated into 3 groups:stable angina pectoris(SAP) group(n =30),unstable angina pectoris(UAP) group(n =29),and acute myocardial infarction (AMI) group (n =26).Correlation between plasma levels of Jaggedl and VEGF was analyzed.Results:The plasma levels of Jagged1 and VEGF were significantly higher in SAP group,UAP group,AMI group compared with those in the healthy controls.In CHD patients,the levels of Jaggedl and VEGF increased in the order of SAP group,UAP group,AMI group(P ＜ 0.05).The plasma level of Jaggedl was positively correlated with that of VEGF(r =0.708,P ＜ 0.01).Conclusion:The plasma level of Jagged1 is significantly higher in CHD patients and is positively correlated with VEGF,which indicates that the plasma level of Jaggedl is correlated with CHD.