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自从一氧化氮 (NO)发现后的 1 0多年时间里 ,已对它进行广泛而深入的研究 ,发现它与肾脏的病理过程关系极为密切。但到目前为止 ,NO在肾损伤中的确切作用仍有较大争论 ,它有抗损伤的一面 ,包括 :改善肾内血液循环、抑制系膜组织增生和系膜细胞收缩、抑制炎症细胞浸润和延缓间质纤维化、调节免疫应答 ;又有促进损伤的一面 ,包括 :促进系膜细胞坏死和促进系膜细胞增生和基质沉积。它最终的作用由微环境中NO的浓度以及它与其它炎症因子相互作用的结果所决定。明确并调整肾损伤过程中NO产生的失衡 ,可能有利于肾损伤的治疗。
It has been extensively and deeply studied since the discovery of nitric oxide (NO) for more than 10 years and found that it has a close relationship with the pathological process of the kidney. So far, however, the exact role of NO in renal injury remains controversial as it has an anti-injury side that includes improving renal blood circulation, inhibiting mesangial cell proliferation and mesangial cell contraction, and inhibiting inflammatory cell infiltration and Delaying interstitial fibrosis, regulating immune response; there are other aspects of promoting damage, including: to promote mesangial cell necrosis and promote mesangial cell proliferation and matrix deposition. Its ultimate effect is determined by the concentration of NO in the microenvironment and the result of its interaction with other inflammatory factors. To clarify and adjust the imbalance of NO during renal injury may be beneficial to the treatment of renal injury.