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目的观察普贝生促宫颈成熟的临床效果及其安全性。方法将61例无阴道分娩禁忌、单胎、胎位正常,有引产指征的足月待产孕妇随机分为2组:试验组30例:将普贝生一枚放置于阴道后穹窿,若无不良反应,临产后取出,若无临产,12h取出;对照组31例:静滴0.5%催产素,据宫缩情况调整滴速,于用药后6h及12h分别进行宫颈Bishop评分,比较二组的宫颈成熟情况,及对胎儿及新生儿的影响。结果用药后6、12h宫颈评分普贝生组明显高于对照组;12h后普贝生组宫颈成熟的比率及显效率和有效率均明显高于对照组;两组新生儿结局无明显差异。有1例发生过敏反应、恶心、呕吐、心率过速,发生在用药5min,取出后好转;3例宫缩过强,发生在用药2h,取出后好转,均未导致不良后果。结论普贝生是一种有效和安全的促宫颈成熟药物,对母儿无明显不良影响。
Objective To observe the clinical effect and safety of Przewalski’s cervical ripening. Methods Totally 61 pregnant women with non-vaginal delivery contraindications, single births, normal fetal position and induction of labor were randomly divided into two groups: 30 in the experimental group: one in Pusheng placed in the vaginal fornix, Reaction, abortion after labor, if no labor, 12h removed; control group of 31 patients: intravenous infusion of 0.5% oxytocin, according to the contractions adjust the drip rate, at 6h and 12h after treatment, respectively, cervical Bishop score, Mature, and the impact on the fetus and newborn. Results The scores of cervical maturation and the effective rate of cervical maturation were significantly higher than those of the control group at 6 and 12 hours after treatment. The neonatal outcomes of the two groups were not significantly different. There was 1 case of allergic reaction, nausea, vomiting, heart rate overdose, occurred in the medication 5min, removed after the improvement; 3 cases of contractions too strong occurred in the medication 2h, removed after the improvement, did not lead to adverse consequences. Conclusion Pu Bei Sheng is an effective and safe cervical ripening drug, no significant adverse effects on the mother and child.