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自从70年代初期Rowsell等证实麦角胺可引起头痛以来,目前已明确某些药物的过量使用可引起头痛(MIH),常见的有止痛剂(如对乙酰氨基酚、阿司匹林)、鸦片类、麦角胺、舒马普坦等。易患头痛而过量使用止痛剂的病人会产生一种症状,其特征为每天出现药物依赖的而又难以用药物防治的头痛,此现象被称之为:止痛剂伴有的头痛、止痛剂反跳性头痛、慢性张力性头痛、医源性头痛、变异性头痛等,停用止痛剂会产生撤退症状以及一段时间内头痛加剧随之而来的是头痛缓解。 1 对药物性头痛的认识 1988年国际头痛学会制定了一套头痛分类。1990年Mathew提出了药物诱发难治性头痛的特征:①初发头痛患者每日频繁的、过量的使用止痛剂;②头痛治疗中出现对
Since the early 1970s, Rowsell and other confirmed that ergotamine can cause headaches, it has been clear that the overuse of certain drugs can cause headache (MIH), the common analgesics (such as acetaminophen, aspirin), opiates, ergotamine , Sumatriptan and so on. Patients prone to headaches and overdose of analgesics develop symptoms that are characterized by daily drug-dependent headaches that are difficult to control with medication, a phenomenon known as headache associated with analgesics, analgesics Jump headache, chronic tension headache, iatrogenic headache, variability headache, withdrawal of painkillers will have withdrawal symptoms and increased headache over time is followed by headache relief. 1 awareness of drug-induced headache 1988 International Headache Society developed a set of headache classification. Mathew in 1990 proposed the characteristics of drug-induced refractory headache: ① first-episode headache patients daily frequent, excessive use of analgesics; ② headache treatment in the right