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目的探讨早产儿重度脑室周围-脑室内出血的高危因素。方法选择2008—2009年我院新生儿重症监护病房重度脑室周围-脑室内出血的早产儿为观察组,同期轻度脑室周围-脑室内出血早产儿为对照组,对引起早产儿脑室周围-脑室内出血可能的15项临床因素进行统计学分析。结果观察组32例,死亡6例,放弃治疗12例;对照组93例,死亡1例,放弃治疗2例。单因素分析显示,胎龄、出生体重、前置胎盘、产时窒息、宫内窘迫、低氧血症、高碳酸血症、机械通气、吸入高浓度氧等与早产儿重度脑室周围-脑室内出血有关(P均<0.05)。多因素Logistic回归分析显示,胎龄(OR=3.545)、出生体重(OR=3.453)、产时窒息(OR=3.232)、机械通气(OR=3.643)和吸入高浓度氧(OR=3.449)为早产儿重度脑室周围-脑室内出血的高危因素(P均<0.05)。结论早产儿脑室周围-脑室内出血的高危因素较多,而且预后差,早期预防早产儿重度脑室周围-脑室内出血并采取积极干预措施具有重要意义。
Objective To explore the risk factors of severe periventricular-ventricular hemorrhage in preterm infants. Methods The neonatal intensive care unit (NICU) in our hospital from 2008 to 2009 was selected as the observation group. Preterm infants with mild periventricular / intraventricular hemorrhage during the same period were taken as the control group, which may cause premature infants with periventricular-intraventricular hemorrhage The 15 clinical factors for statistical analysis. Results The observation group of 32 cases, 6 cases of death, give up treatment in 12 cases; control group of 93 cases, 1 died, give up treatment in 2 cases. Univariate analysis showed that gestational age, birth weight, placenta previa, asphyxia during labor, intrauterine distress, hypoxemia, hypercapnia, mechanical ventilation, high concentrations of oxygen inhalation and preterm children with severe periventricular - intraventricular hemorrhage Related (P <0.05). Multivariate logistic regression analysis showed that gestational age (OR = 3.545), birth weight (OR = 3.453), asphyxia during labor (OR = 3.232), mechanical ventilation (OR = 3.643) and high concentration of oxygen inhalation Preterm infants with severe periventricular-intraventricular hemorrhage risk factors (P <0.05). Conclusions The risk factors of periventricular - intraventricular hemorrhage in preterm infants are high, and the prognosis is poor. It is of great importance to prevent severe periventricular - intraventricular hemorrhage in early infants and take active interventions.