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本文评价大剂量顺铂（HD-DDP）、硫代硫酸钠（STS）双途径疗法治疗癌性胸腹水的疗效。DDP按120～150mg·m2胸、腹腔内注射，同时静滴STS以解救全身毒性。结果36例患者共计50个疗程，控制胸腹水总有效率75％（27／36），其中胸水（CR十PR）84．2％，腹水（CR＋PR）64．7％；有效病例中位缓解期3．3个月。毒副反应主要是恶心、呕吐，经对症处理均在治疗后2～3天消失。HD—DDP、STS双途径疗法治疗癌性胸腹水具有疗效显著，操作简便、安全、经济及毒副反应轻，患者均能接受的优点，值得临床进一步改进，推广应用。
This article evaluated the efficacy of high-dose cisplatin (HD-DDP) and sodium thiosulfate (STS) dual-pathway therapy for cancerous pleural effusion and ascites. DDP was intraperitoneally injected with 120-150 mg·m2 of thoracic cavity and STS was intravenously administered to rescue systemic toxicity. Results The 36 patients had a total of 50 courses and the total effective rate of thoracentesis was 75% (27/36). Among them, pleural effusion (CR 10 PR) was 84.2%, ascites fluid (CR+PR) 64.7%; effective case median remission period 3.3 months. The toxic side effects were mainly nausea and vomiting. Symptomatic treatment disappeared 2 to 3 days after treatment. HD-DDP, STS dual-pathway treatment of cancerous hydrothorax and ascites has a significant effect, easy operation, safety, economical and toxic side effects, patients can accept the advantages, it is worth further clinical improvement, promotion and application.