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目的:探讨2型糖尿病患者血清肝细胞生长因子(HGF)水平与清蛋白尿的相关性。方法:采用ELISA法检测120例尿清蛋白排泄率(UAER)水平的2型糖尿病患者和30例健康体检者的血清肝细胞生长因子(HGF)水平。结果:从对照组、正常清蛋白尿组到临床清蛋白尿组,受试者的血清HGF、UAER和空腹血糖(FBG)水平依次增高,差异均有统计学意义,均P<0.01。糖尿病患者血清HGF水平与UAER(γ=0.889,P<0.01)呈显著正相关,与FBG(γ=0.586,P<0.01)呈显著正相关。结论:2型糖尿病患者血清肝细胞生长因子水平随尿清蛋白排泄率的增加而明显增加,且两者间密切相关,HGF水平检测有利于患者的病情评估,有利于早期诊断。
Objective: To investigate the relationship between serum hepatocyte growth factor (HGF) and albuminuria in type 2 diabetic patients. Methods: Serum levels of hepatocyte growth factor (HGF) were measured in 120 type 2 diabetic patients with urinary albumin excretion (UAER) and 30 healthy controls by ELISA. Results: The levels of serum HGF, UAER and fasting blood glucose (FBG) in control group, normal albuminuria group and clinical albuminuria group were significantly higher than those in control group (all P <0.01). Serum HGF level in diabetic patients was positively correlated with UAER (γ = 0.889, P <0.01), and positively correlated with FBG (γ = 0.586, P <0.01). Conclusion: The serum levels of hepatocyte growth factor (HGF) in patients with type 2 diabetes mellitus (T2DM) significantly increase with the increase of urinary albumin excretion rate, and the two are closely related to each other. HGF level is beneficial to the evaluation of patients’ condition and is beneficial to early diagnosis.