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目的探讨血浆vWF水平与高血压合并冠心病患者的血压昼夜节律变化的关系。方法入选2014年11月-2015年12月本院160例高血压合并冠心病的患者,对患者行24小时动态血压监测,依据夜间收缩压较白昼收缩压下降百分率分为杓型组(n=23)、非杓型组(n=70)和反杓组(n=67)组。应用酶联免疫吸附测定(ELISA)检测患者血浆vWF水平。结果各组一般临床资料比较三组的年龄、性别、体重指数(BMI)、血脂、胆固醇、高密度脂蛋白、低密度脂蛋白、肌酐、诊室收缩压(SBP)、舒张压(DBP)比较差异无统计学意义(P>0.05)。非杓型组、反杓型组的nSBP较杓型组明显升高(P<0.05),反杓型组nSBP较非杓型组明显升高(P<0.05)。血浆vWF水平非杓型组明显高于杓型组(984.74±219.27,717.32±241.09 P<0.05),比较差异有统计学意义,反杓型组与杓型组比较有差异(1019.99±256.64,717.32±241.09 P<0.05)。结论血浆vWF水平高血压合并冠心病的患者与血压节律相关。
Objective To investigate the relationship between plasma vWF levels and changes of circadian rhythm of blood pressure in patients with hypertension and coronary heart disease. Methods One hundred and sixty patients with hypertension complicated with coronary heart disease in our hospital from November 2014 to December 2015 were enrolled in this study. The patients were monitored for ambulatory blood pressure 24 hours a day and were divided into dipper group (n = 23), non-dipper group (n = 70) and anti-dipper group (n = 67). Plasma vWF levels were measured by enzyme-linked immunosorbent assay (ELISA). Results The clinical data of the three groups were compared in terms of age, sex, body mass index (BMI), blood lipids, cholesterol, HDL, LDL, creatinine, SBP and DBP No statistical significance (P> 0.05). The nSBP of the non-dipper group and the anti-dipper group was significantly higher than that of the dipper group (P <0.05). The nSBP of the anti-dipper group was significantly higher than that of the non-dipper group (P <0.05). The level of plasma vWF in non-dipper group was significantly higher than that in dipper group (984.74 ± 219.27, 717.32 ± 241.09, P <0.05), and the difference was statistically significant (P <0.01) ± 241.09 P <0.05). Conclusions Plasma vWF levels are associated with blood pressure rhythm in patients with hypertension and coronary heart disease.