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目的:探讨Mina53(Myc—induced nuclear antigen 53)在肾细胞癌中的表达及意义。方法:利用免疫组化SP法测定96例经HE病理确诊RCC组织和20例癌旁组织中Mina53的表达,并分析其结果与病理分级及l临床分期之间的关系。结果:Mina53在癌旁组织和Ⅰ期、Ⅱ期RCC组织中不表达或低表达,在Ⅲ期、Ⅳ期RCC组织中高表达,在Ⅳ期与Ⅰ、Ⅱ、Ⅲ期间的表达差异有统计学意义(P<0.01);在不同的病理分级G_3与G_2,G_3与G_1中表达差异有统计学意义(P<0.05)。结论:Mina53在RCC组织中的表达与临床病理分期、分级有关,随着病理分级和临床分期的升高而增强,Mina53的高表达与肾细胞癌的临床进展有关。
Objective: To investigate the expression of Mina53 (Myc-induced nuclear antigen 53) in renal cell carcinoma and its significance. Methods: Immunohistochemical SP method was used to determine the expression of Mina53 in 96 cases of RCC tissues and 20 cases of paracancerous tissues by HE pathology. The relationship between Mina53 expression and pathological grade and clinical stage was analyzed. Results: Mina53 was not expressed or down-regulated in paracancer tissues and stage I and stage II RCC tissues, and was highly expressed in stage III and stage IV RCC tissues. There was a significant difference between stage IV and stage I, II and III (P <0.01). There was a significant difference in the expression of G_3, G_2, G_3 and G_1 in different pathological grades (P <0.05). Conclusion: The expression of Mina53 in RCC tissues is correlated with the clinical stage and grading, and with the increase of pathological grade and clinical stage, the expression of Mina53 is correlated with the clinical progress of renal cell carcinoma.